Back to discover
Disease

Adverse effect

Late-stage therapeutic development

Also known as adverse reaction.

11
Clinical trials
12
Associated genes
2
Related proteins
Current focus
Cholinesterase biologyProstacyclin biologyTherapeutic development

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low
Key developments
  • 1 clinical trial expected to report results, the earliest in Q1 2027.
Upcoming Milestones
Major developments
Upcoming trial readoutImportant
Propofol and Etomidate Admixtures Comparisons Trial (PEAC Trial)
Results expected Q1 20272026-01-20
Major clinical milestoneWorth watching
Pre-treatment With Azithromycin to Reduce Immunogenicity to Anti-Tumor Necrosis Factor-α Agents in Patients With Crohn's Disease
Primary completion2025-12-31
Clinical Milestones2View
Results expected 1
Recently completed 1
Activity timeline2

Clinical trials

11 sponsors · 0 new · 0 completed in the last 12 months (net +0)

The current development programme across all trial phases.

Clinical programme
11
All trials
2
Active
7
Late-stage
6
Completed
Late-stage studies

Propofol and Etomidate Admixtures Comparisons Trial (PEAC Trial)

Phase 3 · Recruiting · University of Texas Southwestern Medical Center

Granisetron Versus Pethidine in Treatment of Post Spinal Shivering in Cesarean Sections

Phase 4 · Completed · Ain Shams University

The Effect of Opioid Free Anesthesia on the Postoperative Opioid Consumption in Laparoscopic Bariatric Surgeries: Randomized Controlled Study

Phase 4 · Completed · Tanta University

Postoperative Consequences of Intraoperative NOL Titration

Phase 3 · Completed · The Cleveland Clinic

Immunogenicity and Safety of A Lyophilized Purified Human Diploid Cell Rabies Vaccine in Chinese Healthy People Aged 10-60 Years.: A Randomized, Blinded, Phase III Clinical Trial.

Phase 3 · Completed · Jiangsu Province Centers for Disease Control and Prevention

Comparison Between Different Norepinephrine Bolus Doses for Management of Post-spinal Hypotension During Ceaserian Section for Patients With Preeclampsia

Phase 4 · Completed · Kasr El Aini Hospital
Recruiting

Propofol and Etomidate Admixtures Comparisons Trial (PEAC Trial)

Phase 3 · Recruiting · University of Texas Southwestern Medical Center

Pre-treatment With Azithromycin to Reduce Immunogenicity to Anti-Tumor Necrosis Factor-α Agents in Patients With Crohn's Disease

Phase 2 · Recruiting · Rambam Health Care Campus
Recently completed

Granisetron Versus Pethidine in Treatment of Post Spinal Shivering in Cesarean Sections

Phase 4 · Completed · Ain Shams University

Postoperative Consequences of Intraoperative NOL Titration

Phase 3 · Completed · The Cleveland Clinic

Comparison Between Different Norepinephrine Bolus Doses for Management of Post-spinal Hypotension During Ceaserian Section for Patients With Preeclampsia

Phase 4 · Completed · Kasr El Aini Hospital

The Effect of Opioid Free Anesthesia on the Postoperative Opioid Consumption in Laparoscopic Bariatric Surgeries: Randomized Controlled Study

Phase 4 · Completed · Tanta University

Immunogenicity and Safety of A Lyophilized Purified Human Diploid Cell Rabies Vaccine in Chinese Healthy People Aged 10-60 Years.: A Randomized, Blinded, Phase III Clinical Trial.

Phase 3 · Completed · Jiangsu Province Centers for Disease Control and Prevention

The Effect of Oral Contraceptive Pills On Macula, Retinal Nerve Fiber Layer and Choroid Thickness

Phase 4 · Completed · Kayseri Education and Research Hospital

Associated genes

12 matches

Genes associated with this disease in the canonical knowledge graph (Open Targets evidence). Number shows the association score.

GPRC5A0.38DKK30.33CCDC85A0.32PTGIR0.31TMEM2330.31BEND30.31MTX30.31BCHE0.30RMDN20.29DHRS120.28PAWR0.28ATP9B0.28

Disease biology

2 matches

Proteins whose encoding gene is associated with this disease, reached through the canonical gene→disease graph. Number shows the gene's association score.

Prostacyclin receptorvia PTGIR0.31Cholinesterasevia BCHE0.30

Reference

Authoritative identity, definition & identifiers.

Synonyms

adverse reaction

References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.