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DLG4

Gene

discs large MAGUK scaffold protein 4

HGNCHGNC:2903EnsemblENSG00000132535NCBI Gene1742
Locus: gene with protein productLocation: 17p13.1

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Disks large homolog 4P78352

Protein · therapeutic target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asPSD-95 · PSD95 · SAP90 · SAP-90
View full nomenclature history (6)
Alias symbolsPSD-95, PSD95, SAP90, SAP-90
Previous namesdiscs, large homolog 4 (Drosophila), discs large homolog 4

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Genetic Diseases, Inborn
Neurodegenerative Diseases
Complex neurodevelopmental disorder
Autoimmune disorder of central nervous system

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Membrane associated guanylate kinasesPDZ domain containing

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2026-06-18.
Open TargetsGene–disease associations from the Open Targets Platform.