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DLST

Gene

dihydrolipoamide S-succinyltransferase

HGNCHGNC:2911EnsemblENSG00000119689NCBI Gene1743
Locus: gene with protein productLocation: 14q24.3

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asDLTS · OGDC-E2 · KGD2
View full nomenclature history (6)
Previous symbolsDLTS
Alias symbolsOGDC-E2, KGD2
Previous namesdihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)
Alias namesDihydrolipoyllysine-residue succinyltransferase, 2-oxoglutarate dehydrogenase complex component E2

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Paraganglioma
Neurodegenerative Diseases
Major depressive disorder
Respiratory Tract Infections
Lysosomal Storage Diseases

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Oxoglutarate dehydrogenase complex subunitsOxoadipate dehydrogenase complex subunits

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.