EDNRA

Gene

endothelin receptor type A

HGNCHGNC:3179 EnsemblENSG00000151617 NCBI Gene1909

Locus: gene with protein productLocation: 4q31.22-q31.23

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Endothelin-1 receptorP25101

Protein · therapeutic target

Clinically validated target · 8 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asET-A · ETA-R · hET-AR

View full nomenclature history (3)

Alias symbolsET-A, ETA-R, hET-AR

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Hypertension

Pulmonary arterial hypertension

Hypertension, Pulmonary

Scleroderma, Systemic

Cardiovascular Diseases

Glomerulonephritis, IGA

Coronary Artery Disease

Prostatic Neoplasms

Heart Diseases

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Endothelin receptors

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-03-15.

Open TargetsGene–disease associations from the Open Targets Platform.