EGFR

Gene

epidermal growth factor receptor

HGNCHGNC:3236 EnsemblENSG00000146648 NCBI Gene1956

Locus: gene with protein productLocation: 7p11.2

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Epidermal growth factor receptorP00533

Protein · therapeutic target

Clinically validated target · 28 approved medicines against this target

Member of “ErbB Receptors” · 51 related family papers (context, not papers about this gene)

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asERBB · ERBB1 · ERRP

View full nomenclature history (6)

Previous symbolsERBB

Alias symbolsERBB1, ERRP

Previous namesepidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)

Alias nameserythroblastic leukemia viral (v-erb-b) oncogene homolog (avian), erb-b2 receptor tyrosine kinase 1

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Carcinoma, Non-Small-Cell Lung

Adenocarcinoma of Lung

Neoplasms

Squamous Cell Carcinoma of Head and Neck

Lung Neoplasms

Breast Neoplasms

Colorectal adenocarcinoma

Glioblastoma

Inflammatory skin and bowel disease, neonatal, 2

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Erb-b2 receptor tyrosine kinases

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-03-15.

Open TargetsGene–disease associations from the Open Targets Platform.