EGLN2

Gene

egl-9 family hypoxia inducible factor 2

HGNCHGNC:14660 EnsemblENSG00000269858 NCBI Gene112398

Locus: gene with protein productLocation: 19q13.2

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Prolyl hydroxylase EGLN2Q96KS0

Protein · therapeutic target

Clinically validated target · 4 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asPHD1 · HIFPH1

View full nomenclature history (4)

Alias symbolsPHD1, HIFPH1

Previous namesegl nine homolog 2 (C. elegans)

Alias namesHIF prolyl hydroxylase 1

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Anemia

Kidney Failure, Chronic

Neurodegenerative Diseases

Myelodysplastic syndrome

Respiratory Distress Syndrome

Genetic Diseases, Inborn

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Egl-9 family hypoxia inducible factors

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2026-06-10.

Open TargetsGene–disease associations from the Open Targets Platform.