EIF2AK1

Gene

eukaryotic translation initiation factor 2 alpha kinase 1

HGNCHGNC:24921 EnsemblENSG00000086232 NCBI Gene27102

Locus: gene with protein productLocation: 7p22.1

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asHRI · KIAA1369 · hHRI · HCR

View full nomenclature history (7)

Alias symbolsHRI, KIAA1369, hHRI, HCR

Alias namesheme regulated initiation factor 2 alpha kinase, Heme-regulated inhibitor, hemin-controlled repressor

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Genetic Diseases, Inborn

Neurodegenerative Diseases

Endocarditis

Autoimmune disorder of central nervous system

COVID-19

Severe Acute Respiratory Syndrome

Infections

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Eukaryotic translation initiation factor 2 alpha kinases

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.