Back to discover

EIF2AK2

Gene

eukaryotic translation initiation factor 2 alpha kinase 2

HGNCHGNC:9437EnsemblENSG00000055332NCBI Gene5610
Locus: gene with protein productLocation: 2p22.2

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Interferon-induced, double-stranded RNA-activated protein kinaseP19525

Protein · therapeutic target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asPRKR · PKR · PPP1R83
View full nomenclature history (8)
Previous symbolsPRKR
Alias symbolsPKR, PPP1R83
Previous namesprotein kinase, interferon-inducible double stranded RNA dependent
Alias namesprotein phosphatase 1, regulatory subunit 83, Protein Kinase RNA-activated, protein kinase RNA-regulated, Protein Kinase R

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Neurodegenerative Diseases
HIV Infections
Virus Diseases
Influenza, Human
Genetic Diseases, Inborn

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Protein phosphatase 1 regulatory subunitsEukaryotic translation initiation factor 2 alpha kinases

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.