EPCAM

Gene

epithelial cell adhesion molecule

HGNCHGNC:11529 EnsemblENSG00000119888 NCBI Gene4072

Locus: gene with protein productLocation: 2p21

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Epithelial cell adhesion moleculeP16422

Protein · therapeutic target

Clinically validated target · 3 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asM4S1 · MIC18 · TACSTD1 · Ly74 · TROP1 · GA733-2 · EGP34 · EGP40 · EGP-2 · CD326 · Ep-CAM · HEA125 · KS1/4 · MK-1 · MH99 · MOC31 · MOC-31 · 323/A3 · 17-1A · TACST-1 · CO-17A · ESA · BerEp4 · Ber-Ep4 · KSA

View full nomenclature history (28)

Previous symbolsM4S1, MIC18, TACSTD1

Alias symbolsLy74, TROP1, GA733-2, EGP34, EGP40, EGP-2, CD326, Ep-CAM, HEA125, KS1/4, MK-1, MH99, MOC31, MOC-31, 323/A3, 17-1A, TACST-1, CO-17A, ESA, BerEp4, Ber-Ep4, KSA

Previous namesantigen identified by monoclonal antibody AUA1, tumor-associated calcium signal transducer 1

Alias namestrophoblast cell surface antigen 1

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Stomach Neoplasms

Neoplasms

Colorectal Neoplasms, Hereditary Nonpolyposis

Colon carcinoma

Colorectal Neoplasms

Inherited cancer-predisposing syndrome

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

CD moleculesMicroRNA protein coding host genes

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.