Colorectal Neoplasms, Hereditary Nonpolyposis
Recent clinical, regulatory, research and industry developments relating to this disease.
Characterization of mismatch-repair/microsatellite instability-discordant endometrial cancers.
What's happening now
An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.
Research activity
Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.
Major themes7
- Brain Neoplasms1
- Colorectal Neoplasms1
- Colorectal Neoplasms, Hereditary Nonpolyposis1
- Endometrial Neoplasms1
- Microsatellite Repeats1
- Mutation1
- Neoplastic Syndromes, Hereditary1
Leading journals3
- Cancer1
- Journal of the National Cancer Institute1
- The New England journal of medicine1
Leading researchers8
- de la Chapelle A2
- Lynch HT2
- Barrett JC1
- Boland CR1
- Burgart LJ1
- Chassen A1
- Chen W1
- Cohn DE1
Affiliations (unnormalised)4
- Creighton University School of Medicine1
- National Cancer Institute1
- The Ohio State University Comprehensive Cancer Center/James Cancer Hospital1
- The Ohio State University Wexner Medical Center1
Disease biology
Key proteins & gene products studied in this disease. Number shows shared papers.
Related conditions
Diseases frequently studied alongside this one. Number shows shared papers.
Reference
Authoritative identity, definition & identifiers.
A group of autosomal-dominant inherited diseases in which COLON CANCER arises in discrete adenomas. Unlike FAMILIAL POLYPOSIS COLI with hundreds of polyps, hereditary nonpolyposis colorectal neoplasms occur much later, in the fourth and fifth decades. HNPCC has been associated with germline mutations in mismatch repair (MMR) genes. It has been subdivided into Lynch syndrome I or site-specific colonic cancer, and LYNCH SYNDROME II which includes extracolonic cancer.
- Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
- Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
- Related entities are derived from literature co-mention (studied together) — associative, not causal.