Back to discover

MSH6

Gene

mutS homolog 6

HGNCHGNC:7329EnsemblENSG00000116062NCBI Gene2956
Locus: gene with protein productLocation: 2p16.3

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asGTBP · MSH-6
View full nomenclature history (4)
Previous symbolsGTBP
Alias symbolsMSH-6
Previous namesmutS (E. coli) homolog 6, mutS homolog 6 (E. coli)

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Colorectal Neoplasms, Hereditary Nonpolyposis
Endometrial Neoplasms
Colorectal Neoplasms
Colon carcinoma
Ovarian Neoplasms

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

MutS homologsPWWP domain containingBRCA1-associated genome surveillance complex

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-03-15.
Open TargetsGene–disease associations from the Open Targets Platform.