ERBB2

Gene

erb-b2 receptor tyrosine kinase 2

HGNCHGNC:3430 EnsemblENSG00000141736 NCBI Gene2064

Locus: gene with protein productLocation: 17q12

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Receptor tyrosine-protein kinase erbB-2P04626

Protein · therapeutic target

Clinically validated target · 18 approved medicines against this target

Member of “ErbB Receptors” · 51 related family papers (context, not papers about this gene)

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asNGL · NEU · HER-2 · CD340 · HER2 · c-ERB2 · c-ERB-2 · MLN-19 · p185(erbB2)

View full nomenclature history (14)

Previous symbolsNGL

Alias symbolsNEU, HER-2, CD340, HER2, c-ERB2, c-ERB-2, MLN-19, p185(erbB2)

Previous namesv-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2, v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)

Alias namesneuro/glioblastoma derived oncogene homolog, human epidermal growth factor receptor 2, metastatic lymph node gene 19

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Carcinoma, Non-Small-Cell Lung

Neoplasms

Stomach Neoplasms

Breast Neoplasms

Gastric adenocarcinoma

Urinary Bladder Neoplasms

Adenocarcinoma of Lung

HER2 positive breast carcinoma

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

CD moleculesMinor histocompatibility antigensErb-b2 receptor tyrosine kinasesMicroRNA protein coding host genes

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.