ERBB4

Gene

erb-b2 receptor tyrosine kinase 4

HGNCHGNC:3432 EnsemblENSG00000178568 NCBI Gene2066

Locus: gene with protein productLocation: 2q34

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Receptor tyrosine-protein kinase erbB-4Q15303

Protein · therapeutic target

Clinically validated target · 6 approved medicines against this target

Member of “ErbB Receptors” · 51 related family papers (context, not papers about this gene)

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asALS19 · HER4

View full nomenclature history (5)

Alias symbolsALS19, HER4

Previous namesv-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4, v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4

Alias nameshuman epidermal growth factor receptor 4

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Carcinoma, Non-Small-Cell Lung

Amyotrophic Lateral Sclerosis

Neoplasms

Breast Neoplasms

Medullary thyroid gland carcinoma

Polycystic Ovary Syndrome

Atrial Fibrillation

Genetic Diseases, Inborn

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Erb-b2 receptor tyrosine kinasesMicroRNA protein coding host genes

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.