ERLIN2

Gene

ER lipid raft associated 2

HGNCHGNC:1356 EnsemblENSG00000147475 NCBI Gene11160

Locus: gene with protein productLocation: 8p11.23

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asSPFH2 · SPG18 · C8orf2 · NET32 · Erlin-2

View full nomenclature history (8)

Previous symbolsSPFH2, SPG18, C8orf2

Alias symbolsNET32, Erlin-2

Previous namesSPFH domain family, member 2, spastic paraplegia 18 (autosomal dominant), chromosome 8 open reading frame 2

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Spastic Paraplegia, Hereditary

Neoplasms

Bone development disease

Neurodegenerative Diseases

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.