Spastic Paraplegia, Hereditary
Recent clinical, regulatory, research and industry developments relating to this disease.
What's happening now
An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.
Clinical trials
The current development programme across all trial phases.
Research activity
Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.
Major themes3
- Heredodegenerative Disorders, Nervous System1
- Mixed Function Oxygenases1
- Spastic Paraplegia, Hereditary1
Leading journals1
- Genes1
Leading researchers8
- Abicht A1
- Arnold P1
- German A1
- Jukic J1
- Laner A1
- Mennecke A1
- Regensburger M1
- Schmidt MA1
Affiliations (unnormalised)4
- Center for Rare Diseases (ZSEER)1
- Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU)1
- Institute of Functional and Clinical Anatomy1
- Institute of Neuroradiology1
Associated genes
Genes associated with this disease in the canonical knowledge graph (Open Targets evidence). Number shows the association score.
Disease biology
Proteins whose encoding gene is associated with this disease, reached through the canonical gene→disease graph. Number shows the gene's association score.
Reference
Authoritative identity, definition & identifiers.
A group of inherited diseases that share similar phenotypes but are genetically diverse. Different genetic loci for autosomal recessive, autosomal dominant, and x-linked forms of hereditary spastic paraplegia have been identified. Clinically, patients present with slowly progressive distal limb weakness and lower extremity spasticity. Peripheral sensory neurons may be affected in the later stages of the disease. (J Neurol Neurosurg Psychiatry 1998 Jan;64(1):61-6; Curr Opin Neurol 1997 Aug;10(4):313-8)
- Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
- Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
- Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
- Related entities are derived from literature co-mention (studied together) — associative, not causal.