Back to discover

SPG11

Gene

SPG11 vesicle trafficking associated, spatacsin

HGNCHGNC:11226EnsemblENSG00000104133NCBI Gene80208
Locus: gene with protein productLocation: 15q21.1

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asALS5 · FLJ21439
View full nomenclature history (6)
Previous symbolsALS5
Alias symbolsFLJ21439
Previous namesKIAA1840, spastic paraplegia 11 (autosomal recessive), amyotrophic lateral sclerosis 5
Alias namesspatacsin

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Spastic Paraplegia, Hereditary
Genetic Diseases, Inborn
Metabolic Diseases

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.