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AP5Z1

Gene

adaptor related protein complex 5 subunit zeta 1

HGNCHGNC:22197EnsemblENSG00000242802NCBI Gene9907
Locus: gene with protein productLocation: 7p22.1

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asSPG48 · zeta
View full nomenclature history (5)
Alias symbolsSPG48, zeta
Previous namesKIAA0415, adaptor-related protein complex 5, zeta 1 subunit, adaptor related protein complex 5 zeta 1 subunit

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Spastic Paraplegia, Hereditary
Neurodegenerative Diseases
Genetic Diseases, Inborn
Restless Legs Syndrome
Poisoning

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Armadillo like helical domain containingAdaptor related protein complex 5

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.