SPG7

Gene

SPG7 matrix AAA peptidase subunit, paraplegin

HGNCHGNC:11237 EnsemblENSG00000197912 NCBI Gene6687

Locus: gene with protein productLocation: 16q24.3

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asCMAR · CAR · SPG5C

View full nomenclature history (6)

Previous symbolsCMAR

Alias symbolsCAR, SPG5C

Previous namescell matrix adhesion regulator, spastic paraplegia 7 (pure and complicated autosomal recessive)

Alias namesparaplegin

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Spastic Paraplegia, Hereditary

Genetic Diseases, Inborn

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

AAA ATPases

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.