ESR1

Gene

estrogen receptor 1

HGNCHGNC:3467 EnsemblENSG00000091831 NCBI Gene2099

Locus: gene with protein productLocation: 6q25.1-q25.2

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Estrogen receptorP03372

Protein · therapeutic target

Clinically validated target · 37 approved medicines against this target

Member of “Receptors, Estrogen” · 35 related family papers (context, not papers about this gene)

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asESR · ER · NR3A1 · Era · ER-alpha

View full nomenclature history (10)

Previous symbolsESR

Alias symbolsER, NR3A1, Era, ER-alpha

Alias namesnuclear receptor subfamily 3 group A member 1, estrogen receptor alpha, oestrogen receptor alpha, E2 receptor alpha, estradiol receptor

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Estrogen resistance syndrome

Acne Vulgaris

Hypogonadism

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Estrogen receptors

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-08-02.

Open TargetsGene–disease associations from the Open Targets Platform.