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F12

Gene

coagulation factor XII

HGNCHGNC:3530EnsemblENSG00000131187NCBI Gene2161
Locus: gene with protein productLocation: 5q35.3

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

View full nomenclature history (2)
Previous namescoagulation factor XII (Hageman factor)
Alias namesPlasma coagulation Factor XIIa

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Angioedemas, Hereditary
Peptic ulcer disease
Angioedema
Urticaria

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Serine proteasesKringle domain containingCoagulation factors

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-08-03.
Open TargetsGene–disease associations from the Open Targets Platform.