F2R

Gene

coagulation factor II thrombin receptor

HGNCHGNC:3537 EnsemblENSG00000181104 NCBI Gene2149

Locus: gene with protein productLocation: 5q13.3

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Proteinase-activated receptor 1P25116

Protein · therapeutic target

Clinically validated target · 2 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asTR · CF2R · PAR1 · PAR-1

View full nomenclature history (6)

Alias symbolsTR, CF2R, PAR1, PAR-1

Previous namescoagulation factor II (thrombin) receptor

Alias namesprotease activated receptor 1

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Myocardial Infarction

Neurodegenerative Diseases

Peripheral Arterial Disease

Stroke

Pre-Eclampsia

von Willebrand disease 1

Dermatitis

Neoplasms

Coronary Artery Disease

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

F2R receptors

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.