FGD4

Gene

FYVE, RhoGEF and PH domain containing 4

HGNCHGNC:19125 EnsemblENSG00000139132 NCBI Gene121512

Locus: gene with protein productLocation: 12p11.21

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asFRABP · frabin · ZFYVE6 · CMT4H

View full nomenclature history (5)

Alias symbolsFRABP, frabin, ZFYVE6, CMT4H

Previous namesFGD1 family, member 4

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Charcot-Marie-Tooth Disease

Genetic Diseases, Inborn

Head and Neck Neoplasms

Joint Diseases

Hypertension

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Zinc fingers FYVE-typePleckstrin homology domain containingDbl family Rho GEFs

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-03-15.

Open TargetsGene–disease associations from the Open Targets Platform.