FGFR1

Gene

fibroblast growth factor receptor 1

HGNCHGNC:3688 EnsemblENSG00000077782 NCBI Gene2260

Locus: gene with protein productLocation: 8p11.23

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Fibroblast growth factor receptor 1P11362

Protein · therapeutic target

Clinically validated target · 12 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asFLT2 · KAL2 · H2 · H3 · H4 · H5 · CEK · FLG · BFGFR · N-SAM · CD331

View full nomenclature history (13)

Previous symbolsFLT2, KAL2

Alias symbolsH2, H3, H4, H5, CEK, FLG, BFGFR, N-SAM, CD331

Previous namesfms-related tyrosine kinase 2

Alias namesPfeiffer syndrome

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Hypogonadotropic hypogonadism 2 with or without anosmia

Hartsfield-Bixler-Demyer syndrome

Pfeiffer syndrome

Osteoglophonic dysplasia

Hypogonadism

Encephalocraniocutaneous lipomatosis

Neoplasms

Kallmann syndrome

Jackson-Weiss syndrome

Trigonocephaly 1

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

CD moleculesI-set domain containingFibroblast growth factor receptor family

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-03-15.

Open TargetsGene–disease associations from the Open Targets Platform.