FUS

Gene

FUS RNA binding protein

HGNCHGNC:4010 EnsemblENSG00000089280 NCBI Gene2521

Locus: gene with protein productLocation: 16p11.2

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

RNA-binding protein FUSP35637

Protein · therapeutic target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asALS6 · TLS · FUS1 · hnRNP-P2 · HNRNPP2

View full nomenclature history (11)

Previous symbolsALS6

Alias symbolsTLS, FUS1, hnRNP-P2, HNRNPP2

Previous namesfusion, derived from t(12;16) malignant liposarcoma, amyotrophic lateral sclerosis 6, fusion (involved in t(12;16) in malignant liposarcoma), fused in sarcoma

Alias namesheterogeneous nuclear ribonucleoprotein P2, translocated in liposarcoma

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Amyotrophic Lateral Sclerosis

Essential Tremor

Genetic Diseases, Inborn

Liposarcoma

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Zinc fingers RANBP2-typeRNA binding motif containingHeterogeneous nuclear ribonucleoproteinsFET protein family

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.