GDNF

Gene

glial cell derived neurotrophic factor

HGNCHGNC:4232 EnsemblENSG00000168621 NCBI Gene2668

Locus: gene with protein productLocation: 5p13.2

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Glial cell line-derived neurotrophic factorP39905

Protein · therapeutic target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asATF1 · ATF2 · HFB1-GDNF

View full nomenclature history (6)

Alias symbolsATF1, ATF2, HFB1-GDNF

Alias namesastrocyte-derived trophic factor, glial cell line derived neurotrophic factor, glial derived neurotrophic factor

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Diabetes, Gestational

Liver Diseases

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

GDNF family ligands

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.