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Disease

Anorexia Nervosa

Late-stage therapeutic developmentEmerging researchRising momentum
12
Publications
19
Clinical trials
3
Related conditions
2024
Latest publication
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this disease.

Not niche: eating disorders as an example in the dangers of overspecialisation.

Research2024-03-01The British journal of psychiatry : the journal of mental science

Current Discoveries and Future Implications of Eating Disorders.

Research2023-07-08International journal of environmental research and public health

Psychedelics in the treatment of eating disorders: Rationale and potential mechanisms.

Research2023-06-21European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Clinical trials

16 sponsors · 2 new · 1 completed in the last 12 months (net +2)

The current development programme across all trial phases.

Clinical programme
19
All trials
5
Active
8
Late-stage
6
Completed
Late-stage studies
Recently completed

Research activity

12 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Publications over time
20112024
Most influential

Psychedelics in the treatment of eating disorders: Rationale and potential mechanisms.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2023 · 30 cites

Current Discoveries and Future Implications of Eating Disorders.

International journal of environmental research and public health · 2023 · 29 cites

Not niche: eating disorders as an example in the dangers of overspecialisation.

The British journal of psychiatry : the journal of mental science · 2024 · 28 cites
Recent publications
Major themes8
  • Anorexia Nervosa10
  • Bulimia Nervosa3
  • Feeding and Eating Disorders3
  • Major Depressive Disorder3
  • Binge-Eating Disorder2
  • Autism Spectrum Disorder1
  • Bipolar Disorder1
  • Bulimia1
Leading journals6
  • Translational psychiatry2
  • Archives of general psychiatry1
  • BMC psychiatry1
  • European journal of endocrinology1
  • European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology1
  • International journal of environmental research and public health1
Leading researchers8
  • Andreassen OA2
  • Bulik CM2
  • Kaye WH2
  • Adan RAH1
  • Alfredsson L1
  • Ando T1
  • Arcelus J1
  • Babakanian A1
Affiliations (unnormalised)6
  • Institute of Psychiatry2
  • Karolinska Institutet2
  • Norwegian Institute of Public Health2
  • University of Bristol2
  • University of California2
  • University of California San Diego2

Related conditions

3 matches

Diseases frequently studied alongside this one. Number shows shared papers.

Disease profile

A grounded synthesis of the condition — overview, causes, mechanism, risk factors and current standard of care.

Overview

Anorexia nervosa is an eating disorder marked by loss of appetite, intense fear of becoming overweight, disturbance in body image, significant weight loss, and refusal to maintain a minimally normal weight. It is described as occurring most often in adolescent females, and it can have serious physical, psychological, and social consequences.

Causes

The supplied grounding does not identify a single established cause. It supports a psychiatric and psychological framing, with literature also addressing genetics and the role of distressing thoughts and emotions, but it does not specify a definitive aetiology.

Pathophysiology

The grounding describes anorexia nervosa as involving self-induced negative energy balance and the biological effects of starvation and low body weight. Reported physiopathology includes endocrine changes associated with malnutrition and underweight, altered adrenocortical hormones, and disturbances in hunger and satiety regulation. Literature also discusses compulsive exercise and overlap with obsessive-compulsive mechanisms as part of the disorder's neurobiological underpinnings.

Risk factors

Adolescence and female sex are the clearest risk-associated features supported by the grounding, since the disorder occurs most frequently in adolescent females. The literature also notes that eating disorders often develop during adolescence or early adulthood and are associated with preoccupation with food, body weight, and shape, but it does not establish these as causal risk factors.

Current standard of care

Treatment is generally described as a combination of therapy, nutrition counseling, and medical care. The grounding also supports psychotherapy and drug therapy as literature-covered modalities, but it does not specify a standard medication class for anorexia nervosa. Review literature further discusses emerging or experimental approaches such as psychedelic-assisted therapy, but these are not established standard care in the supplied material.

AI-generated summary grounded in MeSH and 6 peer-reviewed sources. Informational only — not medical advice. Generated 2026-07-07.

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

An eating disorder that is characterized by the lack or loss of APPETITE, known as ANOREXIA. Other features include excess fear of becoming OVERWEIGHT; BODY IMAGE disturbance; significant WEIGHT LOSS; refusal to maintain minimal normal weight; and AMENORRHEA. This disorder occurs most frequently in adolescent females. (APA, Thesaurus of Psychological Index Terms, 1994)

References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.