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GJA8

Gene

gap junction protein alpha 8

HGNCHGNC:4281EnsemblENSG00000121634NCBI Gene2703
Locus: gene with protein productLocation: 1q21.2

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asCAE1 · CZP1 · CAE · CX50
View full nomenclature history (8)
Previous symbolsCAE1, CZP1, CAE
Alias symbolsCX50
Previous namesgap junction protein, alpha 8, 50kD (connexin 50), gap junction protein, alpha 8, 50kDa (connexin 50), gap junction protein, alpha 8, 50kDa
Alias namesconnexin 50

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Genetic Diseases, Inborn
Cataract
Total congenital cataract

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Gap junction proteins

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.