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Disease

Cataract

Late-stage therapeutic developmentEmerging researchRising momentum
MeSHCataract
3
Publications
24
Clinical trials
4
Related conditions
2024
Latest publication
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this disease.

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low
Key developments
  • 2 clinical trials expected to report results, the earliest in Q4 2027.
Upcoming Milestones
Clinical Milestones7View
Results expected 2
Recently completed 5
Activity timeline7

Therapeutic landscape

Therapies with a regulatory footing for this condition, alongside the wider set of agents co-studied with it in the literature.

Approved & established therapies
Bromfenac sodium sesquihydrateapproved

Approval — Treatment of postoperative ocular inflammation following cataract extraction in adults. (2011)

Nepafenacapproved

Approval — Nevanac is indicated for: prevention and treatment of postoperative pain and inflammatio… (2007)

Clinical trials

17 sponsors · 3 new · 2 completed in the last 12 months (net +3)

The current development programme across all trial phases.

Clinical programme
24
All trials
6
Active
18
Late-stage
6
Completed
Late-stage studies

A Prospective, Multicenter, Randomized, Masked, Controlled Study to Evaluate the Safety and Efficacy of the Bimatoprost Implant System (78 mcg) Used in Combination With the SpyGlass IOL Compared to Timolol Maleate Ophthalmic Solution, USP, 0.5%,

Phase 3 · Recruiting · SpyGlass Pharma, Inc.

Pain, Anxiety and Anesthetic Satisfaction for Patient With Different State Anxiety Underwent Cataract Surgery With Topical Anesthesia. An Extension Test of Whether to Use Oral Anti-anxiety Drugs (Alprazolam) When Patients Choose Second Eye Cataract Surgery After Unblinding, and Analyze Their Anxiety, Satisfaction and Pain Satisfaction.

Phase 4 · Recruiting · National Taiwan University Hospital

Phase III Clinical Study, to Evaluate the Efficacy and Safety of PRO-232 Ophthalmic Solution on the Ocular Surface of Patients Postoperative to Cataract Surgery by Phacoemulsification.

Phase 3 · Recruiting · Laboratorios Sophia S.A de C.V.

A Phase 3, Multicenter, Randomized, Evaluator-blinded Clinical Trial to Assess the Safety and Efficacy of Clobetasol Propionate Ophthalmic Nanoemulsion, 0.05% Compared to Prednisolone Acetate, 1% in the Treatment of Inflammation After Cataract Surgery in Pediatric Population 0 to 3 Years of Age (CLOSE-3)

Phase 3 · Recruiting · Salvat

The Effects of Ripasudil in Patients With Fuchs Endothelial Corneal Dystrophy Undergoing Femtosecond Laser Assisted Cataract Surgery

Phase 3 · Recruiting · Singapore Eye Research Institute

Evaluating the Efficacy, Compliance, and Patient Satisfaction of a New Dropless Postoperative Regimen After Cataract Surgery in a Vulnerable, County-hospital Population

Phase 4 · Recruiting · University of California, San Francisco
Recruiting

A Prospective, Multicenter, Randomized, Masked, Controlled Study to Evaluate the Safety and Efficacy of the Bimatoprost Implant System (78 mcg) Used in Combination With the SpyGlass IOL Compared to Timolol Maleate Ophthalmic Solution, USP, 0.5%,

Phase 3 · Recruiting · SpyGlass Pharma, Inc.

Pain, Anxiety and Anesthetic Satisfaction for Patient With Different State Anxiety Underwent Cataract Surgery With Topical Anesthesia. An Extension Test of Whether to Use Oral Anti-anxiety Drugs (Alprazolam) When Patients Choose Second Eye Cataract Surgery After Unblinding, and Analyze Their Anxiety, Satisfaction and Pain Satisfaction.

Phase 4 · Recruiting · National Taiwan University Hospital

Phase III Clinical Study, to Evaluate the Efficacy and Safety of PRO-232 Ophthalmic Solution on the Ocular Surface of Patients Postoperative to Cataract Surgery by Phacoemulsification.

Phase 3 · Recruiting · Laboratorios Sophia S.A de C.V.

A Phase 3, Multicenter, Randomized, Evaluator-blinded Clinical Trial to Assess the Safety and Efficacy of Clobetasol Propionate Ophthalmic Nanoemulsion, 0.05% Compared to Prednisolone Acetate, 1% in the Treatment of Inflammation After Cataract Surgery in Pediatric Population 0 to 3 Years of Age (CLOSE-3)

Phase 3 · Recruiting · Salvat

The Effects of Ripasudil in Patients With Fuchs Endothelial Corneal Dystrophy Undergoing Femtosecond Laser Assisted Cataract Surgery

Phase 3 · Recruiting · Singapore Eye Research Institute

Evaluating the Efficacy, Compliance, and Patient Satisfaction of a New Dropless Postoperative Regimen After Cataract Surgery in a Vulnerable, County-hospital Population

Phase 4 · Recruiting · University of California, San Francisco
Recently completed

Cataract Oral vs IV Sedation Pilot RCT: A Non-inferiority Assessment of Perioperative Safety and Cognitive Recovery in Older Adults

Phase 4 · Completed · University of California, San Francisco

Preoperative Pain-Risk Screening and Intervention for Intraoperative Pain in Second-Eye Cataract Surgery Based on Iris Vascular Area Density

Phase 4 · Completed · Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine

Rebamipide Versus Diquafosol-Cyclosporine for Perioperative Dry Eye Disease in Cataract Surgery: A Randomized Trial

Phase 4 · Completed · Samsung Medical Center

The Evaluation of Balanced Salt Solution During Cataract Surgery

Phase 4 · Completed · Adam Fedyk, MD, FACS

Effects of Topical Bromfenac Solution on Macular Thickness in Cataract Patients Undergoing Phacoemulsification Surgery

Phase 4 · Completed · Inas Abd

A Phase 3,Prospective, Randomized, Double-masked, Placebo-controlled, Parallel Study to Evaluate the Efficacy, PK and Safety of 9% Dexamethasone Intraocular Injection for the Treatment of Inflammation Associatedwith Cataract Surgery

Phase 3 · Completed · Ocumension Therapeutics (Shanghai) Co., Ltd

Regulatory timeline

Drug regulatory events matched to this condition by indication — EMA.

First approvals
2011emaApproval — Bromfenac sodium sesquihydrate· Treatment of postoperative ocular inflammation following cataract extraction in adults. source ↗
2007emaApproval — Nepafenac· Nevanac is indicated for: prevention and treatment of postoperative pain and inflammation associated with cataract surgery; reduction in the risk of postoperative macular oedema associated with cataract surgery in diabetic patients. source ↗

European Medicines Agency (CC BY 4.0). Events are matched to this condition by drug indication text — approvals/updates for drugs indicated for it, not disease-specific acts.

Research activity

3 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Publications over time
20172024
Major themes6
  • Global Health2
  • Aging1
  • Cataract1
  • Dementia1
  • Global Burden of Disease1
  • Visual Acuity1
Leading journals2
  • The Lancet. Global health2
  • JAMA network open1
Leading researchers8
  • Ackland P1
  • Andrews SJ1
  • Bourne RRA1
  • Braithwaite T1
  • Brenowitz WD1
  • Buto PT1
  • Casaletto K1
  • Choquet H1
Affiliations (unnormalised)6
  • Anglia Ruskin University1
  • Boston University1
  • Brien Holden Vision Institute1
  • Department of Mathematics and Data Science Institute1
  • Kaiser Permanente Center for Health Research1
  • L V Prasad Eye Institute1

Related conditions

4 matches

Diseases frequently studied alongside this one. Number shows shared papers.

Blindness2Glaucoma2Macular Degeneration2Vision Disorders2

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

Partial or complete opacity on or in the lens or capsule of one or both eyes, impairing vision or causing blindness. The many kinds of cataract are classified by their morphology (size, shape, location) or etiology (cause and time of occurrence). (Dorland, 27th ed)

Identifiers
MeSHCataract
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.