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WFS1

Gene

wolframin ER transmembrane glycoprotein

HGNCHGNC:12762EnsemblENSG00000109501NCBI Gene7466
Locus: gene with protein productLocation: 4p16.1

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asDFNA6 · DFNA14 · DFNA38 · DIDMOAD · WFS
View full nomenclature history (6)
Previous symbolsDFNA6, DFNA14, DFNA38
Alias symbolsDIDMOAD, WFS
Previous namesWolfram syndrome 1 (wolframin)

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Wolfram Syndrome
Diabetes Mellitus, Type 2
Cataract
Diabetes Mellitus
Optic Atrophy

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.