GRIK2

Gene

glutamate ionotropic receptor kainate type subunit 2

HGNCHGNC:4580 EnsemblENSG00000164418 NCBI Gene2898

Locus: gene with protein productLocation: 6q16.3

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Glutamate receptor ionotropic, kainate 2Q13002

Protein · therapeutic target

Clinically validated target · 1 approved medicine against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asGLUR6 · GluR-6 · GluK2 · MRT6 · EAA4 · GLUK6

View full nomenclature history (8)

Previous symbolsGLUR6

Alias symbolsGluR-6, GluK2, MRT6, EAA4, GLUK6

Previous namesglutamate receptor, ionotropic, kainate 2

Alias namesexcitatory amino acid receptor 4‘

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Epilepsy

Migraine Disorders

Alcoholism

Autosomal recessive non-syndromic intellectual disability

Lennox-Gastaut syndrome

Complex neurodevelopmental disorder

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Glutamate ionotropic receptor kainate type subunits

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-25.

Open TargetsGene–disease associations from the Open Targets Platform.