GTF2H2

Gene

general transcription factor IIH subunit 2

HGNCHGNC:4656 EnsemblENSG00000145736 NCBI Gene2966

Locus: gene with protein productLocation: 5q13.2

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asBTF2 · TFIIH · BTF2P44 · T-BTF2P44 · p44

View full nomenclature history (7)

Alias symbolsBTF2, TFIIH, BTF2P44, T-BTF2P44, p44

Previous namesgeneral transcription factor IIH, polypeptide 2 (44kD subunit), general transcription factor IIH, polypeptide 2, 44kDa

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

HIV Infections

Neurodegenerative Diseases

Proximal spinal muscular atrophy

Carcinoma, Hepatocellular

Lung carcinoma

Lung Neoplasms

Neoplasms

Xeroderma Pigmentosum

Muscular Atrophy, Spinal

Breast Neoplasms

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Nucleotide excision repairGeneral transcription factor IIH complex subunits

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.