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GUCY2C

Gene

guanylate cyclase 2C

HGNCHGNC:4688EnsemblENSG00000070019NCBI Gene2984
Locus: gene with protein productLocation: 12p12.3

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Guanylyl cyclase CP25092

Protein · therapeutic target

Clinically validated target · 2 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asGUC2C · GC-C · STAR · HSER · GCC
View full nomenclature history (9)
Previous symbolsGUC2C
Alias symbolsGC-C, STAR, HSER, GCC
Previous namesguanylate cyclase 2C (heat stable enterotoxin receptor)
Alias namesSTA receptor, heat stable enterotoxin receptor, Guanylyl cyclase C

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Irritable Bowel Syndrome
Constipation

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Transmembrane guanylate cyclases

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-06-14.
Open TargetsGene–disease associations from the Open Targets Platform.