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HEY2

Gene

hes related family bHLH transcription factor with YRPW motif 2

HGNCHGNC:4881EnsemblENSG00000135547NCBI Gene23493
Locus: gene with protein productLocation: 6q22.31

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asbHLHb32 · HERP1 · HESR2
View full nomenclature history (5)
Alias symbolsbHLHb32, HERP1, HESR2
Previous nameshairy/enhancer-of-split related with YRPW motif 2, hes-related family bHLH transcription factor with YRPW motif 2

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Atrial Fibrillation
Brugada syndrome
Diabetes Mellitus, Type 2
Migraine Disorders
Obesity disorder
Endometrial Neoplasms
Neurodegenerative Diseases

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Basic helix-loop-helix proteinsHey bHLH transcription factor family

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.