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HTR3A

Gene

5-hydroxytryptamine receptor 3A

HGNCHGNC:5297EnsemblENSG00000166736NCBI Gene3359
Locus: gene with protein productLocation: 11q23.2

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

5-hydroxytryptamine receptor 3AP46098

Protein · therapeutic target

Clinically validated target · 23 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asHTR3 · 5-HT3R · 5-HT3A
View full nomenclature history (5)
Previous symbolsHTR3
Alias symbols5-HT3R, 5-HT3A
Previous names5-hydroxytryptamine (serotonin) receptor 3A, 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Major depressive disorder
Schizophrenia
Neoplasms
Irritable Bowel Syndrome
Depressive Disorder

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

5-hydroxytryptamine receptors, ionotropic

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.