ICOS

Gene

inducible T cell costimulator

HGNCHGNC:5351 EnsemblENSG00000163600 NCBI Gene29851

Locus: gene with protein productLocation: 2q33.2

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asAILIM · CD278

View full nomenclature history (4)

Alias symbolsAILIM, CD278

Previous namesinducible T-cell costimulator

Alias namesactivation-inducible lymphocyte immunomediatory molecule

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Common variable immunodeficiency

Hypothyroidism

Severe Combined Immunodeficiency

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

CD molecules

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.