IFNAR1

Gene

interferon alpha and beta receptor subunit 1

HGNCHGNC:5432 EnsemblENSG00000142166 NCBI Gene3454

Locus: gene with protein productLocation: 21q22.11

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Interferon alpha/beta receptor 1P17181

Protein · therapeutic target

Clinically validated target · 12 approved medicines against this target

Member of “Receptor, Interferon alpha-beta” · 4 related family papers (context, not papers about this gene)

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asIFNAR · IFRC

View full nomenclature history (6)

Previous symbolsIFNAR

Alias symbolsIFRC

Previous namesinterferon (alpha, beta and omega) receptor 1

Alias namesIFNalpha/beta receptor 1, type I interferon receptor 1, interferon alpha/beta receptor 1

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Immunodeficiency 106, susceptibility to viral infections

Lupus Erythematosus, Systemic

Acquired polycythemia vera

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Interferon receptors

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.