IL6ST

Gene

interleukin 6 cytokine family signal transducer

HGNCHGNC:6021 EnsemblENSG00000134352 NCBI Gene3572

Locus: gene with protein productLocation: 5q11.2

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Interleukin-6 receptor subunit betaP40189

Protein · therapeutic target

Clinically validated target · 1 approved medicine against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asGP130 · CD130 · sGP130 · IL-6RB

View full nomenclature history (9)

Alias symbolsGP130, CD130, sGP130, IL-6RB

Previous namesinterleukin 6 signal transducer (gp130, oncostatin M receptor), interleukin 6 signal transducer

Alias namesgp130, oncostatin M receptor, Interleukin-6 receptor subunit beta, membrane glycoprotein 130

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Neuromyelitis Optica

Immune System Diseases

Adenoma, Liver Cell

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

CD moleculesFibronectin type III domain containingInterleukin receptors

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.