INSL3

Gene

insulin like 3

HGNCHGNC:6086 EnsemblENSG00000248099 NCBI Gene3640

Locus: gene with protein productLocation: 19p13.11

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asRLNL · RLF · MGC119818 · MGC119819

View full nomenclature history (7)

Previous symbolsRLNL

Alias symbolsRLF, MGC119818, MGC119819

Previous namesrelaxin-like factor, insulin-like 3 (Leydig cell)

Alias namesprepro-INSL3

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Cryptorchidism

Genetic Diseases, Inborn

46,XY disorder of sex development due to isolated 17,20 lyase deficiency

Spermatogenic failure

Hypogonadism

Kallmann syndrome

46,XY disorder of sex development due to 5-alpha-reductase 2 deficiency

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Receptor ligandsRelaxin family

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.