ITGB2

Gene

integrin subunit beta 2

HGNCHGNC:6155 EnsemblENSG00000160255 NCBI Gene3689

Locus: gene with protein productLocation: 21q22.3

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asCD18 · MFI7 · LFA-1 · MAC-1

View full nomenclature history (7)

Previous symbolsCD18, MFI7

Alias symbolsLFA-1, MAC-1

Previous namesintegrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1; macrophage antigen 1 (mac-1) beta subunit), integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)

Alias namescomplement component 3 receptor 3 and 4 subunit

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Psoriasis vulgaris

Dry Eye Syndromes

Psoriasis

Genetic Diseases, Inborn

Eye Diseases

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

CD moleculesIntegrin beta subunitsComplement system regulators and receptors

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.