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ITIH4

Gene

inter-alpha-trypsin inhibitor heavy chain 4

HGNCHGNC:6169EnsemblENSG00000055955NCBI Gene3700
Locus: gene with protein productLocation: 3p21.1

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asITIHL1 · IHRP · H4P
View full nomenclature history (6)
Previous symbolsITIHL1
Alias symbolsIHRP, H4P
Previous namesinter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein), inter-alpha-trypsin inhibitor heavy chain family, member 4
Alias namesplasma Kallikrein-sensitive glycoprotein

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Coronary Artery Disease
Diabetes Mellitus, Type 2
Hemorrhoid
Diabetes Mellitus
Schizophrenia
Obesity disorder
Major depressive disorder
Anxiety Disorders

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Inter-alpha-trypsin inhibitor heavy chains

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.