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Disease

Hemorrhoid

Late-stage therapeutic development

Also known as Haemorrhoids, Hemorrhoids, hemorrhoidal disease.

12
Clinical trials
12
Associated genes
2
Related proteins
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this disease.

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low
Key developments
  • 1 clinical trial expected to report results, the earliest in Q1 2027.
Upcoming Milestones
Clinical Milestones5View
Results expected 1
Recently completed 4
Activity timeline5

Clinical trials

11 sponsors · 1 new · 1 completed in the last 12 months (net +1)

The current development programme across all trial phases.

Clinical programme
12
All trials
4
Active
7
Late-stage
6
Completed
Late-stage studies

Efficacy and Safety Evaluation of Ruscus Aculeatus L in Patients With Hemorrhoids: A Randomized, Double-blind Phase IV Clinical Trial

Phase 4 · Recruiting · Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey

Efficacy and Safety of Topical Lidocaine 23%/Tetracaine 7% Ointment Versus Placebo for Post-Hemorrhoidectomy Pain: A Double-Blind Randomized Controlled Trial

Phase 4 · Completed · Pontificia Universidad Catolica de Chile

A Prospective, Randomized, Three Arms, Open Label Study Comparing the Safety and Efficacy of Two Formulations of PP110 to the Active Comparator Preparation-H® Cream in the Treatment of Bleeding Hemorrhoids Grades 2-3

Phase 2/3 · Completed · Peritech Pharma Ltd.

A Prospective, Multicentre, Double-Blinded Randomised Controlled Trial Comparing Topical Metronidazole, Diltiazem and Lidocaine on Post-Operative Pain Following Excisional Haemorrhoidectomy

Phase 2/3 · Completed · University of Auckland, New Zealand

A Comparative Clinical Research on Therapeutic Effect and Safety of Compound Carraghenates Cream Versus Mayinglong Musk Hemorrhoid Ointment in the Treatment of Hemorrhoids

Phase 4 · Completed · Xian-Janssen Pharmaceutical Ltd.

The Comparison of the Discharge Conditions and Efficacy of Spinal Anesthesia With Heavy Prilocaine-Fentanyl and Heavy Bupivacaine-Fentanyl in Outpatient Minor Perianal Surgery

Phase 4 · Completed · Diskapi Teaching and Research Hospital
Recently completed

Efficacy and Safety of Topical Lidocaine 23%/Tetracaine 7% Ointment Versus Placebo for Post-Hemorrhoidectomy Pain: A Double-Blind Randomized Controlled Trial

Phase 4 · Completed · Pontificia Universidad Catolica de Chile

A Prospective, Multicentre, Double-Blinded Randomised Controlled Trial Comparing Topical Metronidazole, Diltiazem and Lidocaine on Post-Operative Pain Following Excisional Haemorrhoidectomy

Phase 2/3 · Completed · University of Auckland, New Zealand

A Multicentre, Open-label, Single-arm Phase II Trial on the Efficacy and Safety of Sclerotherapy Using 3% Polidocanol Foam to Treat Second-degree Hemorrhoidal Disease

Phase 2 · Completed · Societa Italiana di Chirurgia ColoRettale

A Prospective, Randomized, Three Arms, Open Label Study Comparing the Safety and Efficacy of Two Formulations of PP110 to the Active Comparator Preparation-H® Cream in the Treatment of Bleeding Hemorrhoids Grades 2-3

Phase 2/3 · Completed · Peritech Pharma Ltd.

The Comparison of the Discharge Conditions and Efficacy of Spinal Anesthesia With Heavy Prilocaine-Fentanyl and Heavy Bupivacaine-Fentanyl in Outpatient Minor Perianal Surgery

Phase 4 · Completed · Diskapi Teaching and Research Hospital

A Comparative Clinical Research on Therapeutic Effect and Safety of Compound Carraghenates Cream Versus Mayinglong Musk Hemorrhoid Ointment in the Treatment of Hemorrhoids

Phase 4 · Completed · Xian-Janssen Pharmaceutical Ltd.

Associated genes

12 matches

Genes associated with this disease in the canonical knowledge graph (Open Targets evidence). Number shows the association score.

MUC120.50MUC3A0.47SRPX0.44ANGPT20.41GDF70.39CAP20.38TPPP0.37IRAG10.36ETAA10.36ITIH40.35MIPOL10.34FEZ20.34

Disease biology

2 matches

Proteins whose encoding gene is associated with this disease, reached through the canonical gene→disease graph. Number shows the gene's association score.

Angiopoietin-2via ANGPT20.41Large ribosomal subunit protein uL6via RPL90.14

Reference

Authoritative identity, definition & identifiers.

Synonyms

Haemorrhoids, Hemorrhoids, hemorrhoidal disease

References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.