JAK1

Gene

Janus kinase 1

HGNCHGNC:6190 EnsemblENSG00000162434 NCBI Gene3716

Locus: gene with protein productLocation: 1p31.3

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Tyrosine-protein kinase JAK1P23458

Protein · therapeutic target

Clinically validated target · 14 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asJAK1B · JAK1A · JTK3

View full nomenclature history (3)

Previous symbolsJAK1B

Alias symbolsJAK1A, JTK3

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Arthritis, Rheumatoid

Autoinflammation, immune dysregulation, and eosinophilia

Graft vs Host Disease

Hypothyroidism

Crohn's Disease

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

FERM domain containingJak family tyrosine kinases

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.