JAK2

Gene

Janus kinase 2

HGNCHGNC:6192 EnsemblENSG00000096968 NCBI Gene3717

Locus: gene with protein productLocation: 9p24.1

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Tyrosine-protein kinase JAK2O60674

Protein · therapeutic target

Clinically validated target · 18 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asJTK10

View full nomenclature history (1)

Alias symbolsJTK10

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Acquired polycythemia vera

Primary myelofibrosis

Myelofibrosis

Colitis, Ulcerative

Myeloproliferative disorder

Crohn's Disease

Neoplasms

Leukemia, Myeloid, Acute

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

SH2 domain containingFERM domain containingJak family tyrosine kinases

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.