KDR

Gene

kinase insert domain receptor

HGNCHGNC:6307 EnsemblENSG00000128052 NCBI Gene3791

Locus: gene with protein productLocation: 4q12

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Vascular endothelial growth factor receptor 2P35968

Protein · therapeutic target

Clinically validated target · 24 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asFLK1 · VEGFR · VEGFR2 · CD309

View full nomenclature history (7)

Alias symbolsFLK1, VEGFR, VEGFR2, CD309

Previous nameskinase insert domain receptor (a type III receptor tyrosine kinase)

Alias namesvascular endothelial growth factor receptor 2, fetal liver kinase 1

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Neoplasms

Carcinoma, Hepatocellular

Gastrointestinal Stromal Tumors

Carcinoma, Renal Cell

Carcinoma, Non-Small-Cell Lung

Gastric adenocarcinoma

Leukemia, Myeloid, Acute

Thyroid gland carcinoma

Colorectal Neoplasms

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

CD moleculesV-set domain containingI-set domain containingVEGF receptor tyrosine kinase family

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.