KEAP1

Gene

kelch like ECH associated protein 1

HGNCHGNC:23177 EnsemblENSG00000079999 NCBI Gene9817

Locus: gene with protein productLocation: 19p13.2

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Kelch-like ECH-associated protein 1Q14145

Protein · therapeutic target

Clinically validated target · 3 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asMGC10630 · MGC1114 · MGC20887 · MGC4407 · MGC9454 · INrf2 · KLHL19 · KIAA0132

View full nomenclature history (9)

Alias symbolsMGC10630, MGC1114, MGC20887, MGC4407, MGC9454, INrf2, KLHL19, KIAA0132

Alias nameskelch-like family member 19

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Multiple Sclerosis

Adenocarcinoma of Lung

Multiple Sclerosis, Relapsing-Remitting

Carcinoma, Non-Small-Cell Lung

Squamous cell lung carcinoma

Psoriasis

Carcinoma, Hepatocellular

Immune System Diseases

Neurodegenerative Diseases

Lung carcinoma

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Kelch likeBTB domain containing

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.