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KLF4

Gene

KLF transcription factor 4

HGNCHGNC:6348EnsemblENSG00000136826NCBI Gene9314
Locus: gene with protein productLocation: 9q31.2

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Krueppel-like factor 4O43474

Protein · therapeutic target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asEZF · GKLF
View full nomenclature history (5)
Alias symbolsEZF, GKLF
Previous namesKruppel-like factor 4 (gut), Kruppel like factor 4
Alias namesgut Kruppel-like factor

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Neurodegenerative Diseases
Prostate carcinoma
Breast Neoplasms
Osteoarthritis, Hip
Cutaneous melanoma
Meningioma

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Zinc fingers C2H2-typeKLF transcription factors

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.