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Disease

Osteoarthritis, Hip

Late-stage therapeutic developmentEmerging research
MeSHOsteoarthritis, Hip
1
Publications
19
Clinical trials
12
Associated genes
9
Related proteins
2008
Latest publication
Current focus
Smoothened biologyTenascin biologyTherapeutic developmentInflammation & immunity
Latest activity
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Recent clinical, regulatory, research and industry developments relating to this disease.

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low
Key developments
  • 1 clinical trial expected to report results, the earliest in Q4 2028.
Upcoming Milestones
Clinical Milestones3View
Results posted 1
Results expected 1
Recently completed 1
Activity timeline3

Clinical trials

18 sponsors · 1 new · 0 completed in the last 12 months (net +1)

The current development programme across all trial phases.

Clinical programme
19
All trials
6
Active
8
Late-stage
6
Completed
Late-stage studies

The Effect of ColcHicine on the Incidence of Knee or Hip Replacements: a Randomized, Double-blind, Multicentre Study in Symptomatic Knee or Hip Osteoarthritis

Phase 3 · Recruiting · Sint Maartenskliniek

The Effect of Dexamethasone Administration Route on Pain and Inflammatory Response in PENG Block for Total Hip Arthroplasty

Phase 4 · Completed · Poznan University of Medical Sciences

Randomized Trial on Spinal Anaesthesia vs. General Anaesthesia (SAGA) on Recovery After Total Hip, Total Knee, and Unicompartmental Knee Arthroplasty

Phase 4 · Completed · Anders Troelsen

A Phase 2/3 (Placebo-Controlled, Double-Blind, Comparative) Study on MT-5547 in Patients With Osteoarthritis Accompanied by Moderate to Severe Pain

Phase 2/3 · Completed · Tanabe Pharma Corporation

A Randomized, Controlled, Double-Blind Trial of 3 Local Anesthetics for Spinal Anesthesia in Primary Total Hip Arthroplasty to Compare the Percentage of Patients in Each Group With Early Ambulation

Phase 4 · Completed · Thomas Jefferson University

Minimal Opioid Use After Total Hip Replacement (THR): a Blinded Randomized Placebo-controlled Study

Phase 4 · Completed · Hospital for Special Surgery, New York
Recently completed

The Effect of Dexamethasone Administration Route on Pain and Inflammatory Response in PENG Block for Total Hip Arthroplasty

Phase 4 · Completed · Poznan University of Medical Sciences

Randomized Trial on Spinal Anaesthesia vs. General Anaesthesia (SAGA) on Recovery After Total Hip, Total Knee, and Unicompartmental Knee Arthroplasty

Phase 4 · Completed · Anders Troelsen

A Phase 2/3 (Placebo-Controlled, Double-Blind, Comparative) Study on MT-5547 in Patients With Osteoarthritis Accompanied by Moderate to Severe Pain

Phase 2/3 · Completed · Tanabe Pharma Corporation

A Randomized, Controlled, Double-Blind Trial of 3 Local Anesthetics for Spinal Anesthesia in Primary Total Hip Arthroplasty to Compare the Percentage of Patients in Each Group With Early Ambulation

Phase 4 · Completed · Thomas Jefferson University

Minimal Opioid Use After Total Hip Replacement (THR): a Blinded Randomized Placebo-controlled Study

Phase 4 · Completed · Hospital for Special Surgery, New York

A PHASE 3 RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, MULTICENTER STUDY OF THE ANALGESIC EFFICACY AND SAFETY OF THE SUBCUTANEOUS ADMINISTRATION OF TANEZUMAB IN SUBJECTS WITH OSTEOARTHRITIS OF THE HIP OR KNEE

Phase 3 · Completed · Pfizer

Research activity

1 paper

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Leading journals1
  • Osteoarthritis and cartilage1
Leading researchers8
  • Abramson S1
  • Altman RD1
  • Arden N1
  • Bierma-Zeinstra S1
  • Brandt KD1
  • Croft P1
  • Doherty M1
  • Dougados M1
Affiliations (unnormalised)1
  • University of Edinburgh1

Associated genes

12 matches

Genes associated with this disease in the canonical knowledge graph (Open Targets evidence). Number shows the association score.

LMX1B0.54COLGALT20.54SMAD30.53NFATC10.53COL11A10.53PLOD20.52ECRG40.52RFLNA0.51TNC0.51TSEN150.51ACAN0.51HHIP0.50

Disease biology

9 matches

Proteins whose encoding gene is associated with this disease, reached through the canonical gene→disease graph. Number shows the gene's association score.

Tenascinvia TNC0.51Beta-nerve growth factorvia NGF0.49Protein smoothenedvia SMO0.46Krueppel-like factor 4via KLF40.40Forkhead box protein O1via FOXO10.39Interleukin-11via IL110.34Integrin alpha-2via ITGA20.25Sex hormone-binding globulinvia SHBG0.23Tumor necrosis factor receptor superfamily member 9via TNFRSF90.15

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

Noninflammatory degenerative disease of the hip joint which usually appears in late middle or old age. It is characterized by growth or maturational disturbances in the femoral neck and head, as well as acetabular dysplasia. A dominant symptom is pain on weight-bearing or motion.

Identifiers
MeSHOsteoarthritis, Hip
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.