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SMAD3

Gene

SMAD family member 3

HGNCHGNC:6769EnsemblENSG00000166949NCBI Gene4088
Locus: gene with protein productLocation: 15q22.33

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asMADH3 · JV15-2 · HsT17436
View full nomenclature history (5)
Previous symbolsMADH3
Alias symbolsJV15-2, HsT17436
Previous namesMAD, mothers against decapentaplegic homolog 3 (Drosophila), SMAD, mothers against DPP homolog 3 (Drosophila)

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Asthma
Osteoarthritis, Hip
Respiratory Tract Diseases
Hypersensitivity

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

SMAD family

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.