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KMT2A

Gene

lysine methyltransferase 2A

HGNCHGNC:7132EnsemblENSG00000118058NCBI Gene4297
Locus: gene with protein productLocation: 11q23.3

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Histone-lysine N-methyltransferase 2AQ03164

Protein · therapeutic target

Clinical-stage target · 2 candidates in clinical development

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asMLL · TRX1 · HRX · ALL-1 · HTRX1 · CXXC7 · MLL1A · MLL1 · ALL1 · HTRX
View full nomenclature history (17)
Previous symbolsMLL
Alias symbolsTRX1, HRX, ALL-1, HTRX1, CXXC7, MLL1A, MLL1, ALL1, HTRX
Previous namesmyeloid/lymphoid or mixed-lineage leukemia (trithorax (Drosophila) homolog), myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila), lysine (K)-specific methyltransferase 2A, Trithorax-like protein, CXXC-type zinc finger protein 7, Acute lymphocytic 1
Alias namesHistone-lysine N-methyltransferase 2A

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Genetic Diseases, Inborn
Leukemia, Myeloid, Acute
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Urinary Bladder Neoplasms
Microcephaly
Melanoma

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

PHD finger proteinsZinc fingers CXXC-typeHistone lysine methyltransferasesBromodomain containingSET domain containing

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.