KRAS

Gene

KRas proto-oncogene, GTPase

HGNCHGNC:6407 EnsemblENSG00000133703 NCBI Gene3845

Locus: gene with protein productLocation: 12p12.1

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

GTPase KRasP01116

Protein · therapeutic target

Clinically validated target · 2 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asKRAS2 · KRAS1 · K-Ras4B

View full nomenclature history (7)

Previous symbolsKRAS2

Alias symbolsKRAS1, K-Ras4B

Previous namesKRAS proto-oncogene, GTPase, v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog, v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, Kirsten rat sarcoma viral oncogene homolog

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Noonan syndrome

Noonan syndrome 3

Cardiofaciocutaneous syndrome 2

Cardiofaciocutaneous syndrome

Carcinoma, Non-Small-Cell Lung

Stomach Neoplasms

Leukemia, Myeloid, Acute

Linear nevus sebaceous syndrome

Toriello-Lacassie-Droste syndrome

Linear nevus sebaceus syndrome

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

RAS type GTPase family

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2026-06-10.

Open TargetsGene–disease associations from the Open Targets Platform.